The stage was easily the hardest of the Giro so far. The first break to succeed consisted of Sylvain Calzati (AG2R) and Staf Scheirlinckx (Cofidis), who went away after 24 km and built a massive 17'48 lead by km 94. But a 30 man chase group formed behind at that point, which gradually whittled down to eight: Vladimir Efimkin (Caisse d'Epargne-Illes Balears), Rik Verbrugghe (Cofidis, le Credit par Telephone), Francisco J. Vila Errandonea (Lampre-Fondital), Serguei Yakovlev (Liberty Seguros-Würth Team), Victor Hugo Pena Grisales (Phonak Hearing Systems), Juan Manuel Garate (Quick Step-Innergetic), Manuele Mori (Saunier Duval-Prodir) and Matthias Kessler (T-Mobile Team).

On the climb of Monte delle Cesane, the lead group reduced to just Verbrugghe, Vila, Pena, Mori and Garate. They managed to stay clear of the peloton almost until the finish, as the Lampre-Fondital led chase tried to set it up for Cunego. But Verbrugghe was too strong today: he attacked the break, which was absorbed by the hard charging bunch in the final 500m, and won the stage.

Paolo Savoldelli (Discovery Channel) led the peloton up the final climb to eventually take second, 14 seconds behind the Belgian, while Luca Mazzanti (Panaria) was third. Serguei Gonchar (T-Mobile) lost a couple of seconds to Savoldelli, but still regained the leader's jersey from his teammate Olaf Pollack.

Robbie arrived in the big group and is still leader in the points classification.